3/23/2023 0 Comments Taghon notched up a levelThe thymic microenvironment gradually converts these immigrating and still multipotent progenitor cells to become T-lineage committed, and also induces extensive proliferation to increase the pool of T cell precursors. Maintenance of physiological thymopoiesis requires the continuous colonization of a small amount of bone marrow (BM) derived T cell precursors whose identity is still unclear in human. T lymphocytes require the specific microenvironment of the thymus for their development. To facilitate and optimize their generation and to enhance T cell recovery in patients, insights into the molecular processes that drive early T cell development after birth are of critical importance. In addition to their protective role against pathogens, T cells are increasingly exploited for immunotherapeutic purposes, particularly through the generation of CAR T-cells. T cell deficiencies result in life-threatening conditions, such as perturbed and delayed T cell reconstitution following chemo- and radiotherapy. T cells are central and essential mediators of the adaptive immune system. Thus, our work resolves the heterogeneity of thymus seeding precursors in human and reveals the molecular mechanisms that drive their in vivo cell fate. Trough trajectory inference, we delineate the transcriptional dynamics underlying early human T-lineage development from which we predict transcription factor modules that drive stage-specific steps of human T cell development. Besides T cell precursors, we discover branches of intrathymic developing dendritic cells with predominantly plasmacytoid DCs. Integration of bone marrow and peripheral blood precursors datasets identifies several putative thymus seeding precursors that display heterogeneity for currently used surface markers as revealed by CITEseq. Here, we employ single-cell RNA sequencing on approximately 70.000 CD34 + thymocytes to unravel the heterogeneity of the human immature postnatal thymocytes. In human, the nature of these thymus immigrants has remained unclear. I knew it was a great school and program, and I fell in love with the campus immediately.Ī: The trees and the architecture, from Campus Walk to Ball Circle to the Bell Tower.Ī: Getting to work with our amazing student-athletes.During postnatal life, thymopoiesis depends on the continuous colonization of the thymus by bone marrow derived hematopoietic progenitors that migrate through the bloodstream. “We want UMW student-athletes to know that they can create the change they want to see in the world by using their platform and voices.”Ī: I came here to work with former women’s lacrosse head coach Caitlin Moore, who is now UMW Athletics assistant director. “The young women on my team were eager to get involved in a way that would impact our campus and community,” she said. The virtual 5K has raised more than $5,000 toward a grant program for the James Farmer Multicultural Center and gained momentum along the way. Inspired by Black Lives Matter, UMW women’s lacrosse teamed up last year with the Black and Jewish student associations, Women of Color, Brothers of a New Direction and the campus NAACP chapter to organize an annual Run for Justice, which took place again this summer. Off the field, Taghon and her players have parlayed their passion into social justice. “I love the creativity and speed of the game.” “It’s amazing watching their confidence grow through such a fun sport,” said Taghon, who earned a bachelor’s degree in history and art history, and coached at Shenandoah University and England’s Ampleforth College. Now the University of Mary Washington’s women’s lacrosse head coach, Taghon imparts her own experience as an athlete – she played defense and midfield at Presbyterian College in South Carolina – on UMW lacrosse players. “All of these opportunities prepared me to coach at the collegiate level.” “From the second I stepped onto the field, I knew this is what I wanted to do,” said Taghon, who has trained players at all levels, from preschoolers to professionals on Britain’s national team. Maddie Taghon, who was named UMW women’s lacrosse head coach in 2020, and her team worked with campus organizations on the annual Run for Justice 5K to raise funds for the James Farmer Multicultural Center.
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